Human Immature Thymocytes as Target Cells of the Leukemogenic Activity
نویسنده
چکیده
The risk of developing adult T-cell leukemia (ATL) associated with neonatal infection by human T-cell leukemia virus type I (HTLV-I) suggests that early events triggered by HTLV-I might be of crucial importance in initiating the multistep lymphoproliferative process leading several decades later to the development of leukemic disease. Thus, infection of thymocytes early in life might be directly correlated with the development of ATL. In the present study, we show that in vitro infection of mature {CD2+CD3’) or immature (CD2+CD3-) thymocytes resulted in the exogenous interleukin (lL)-2-dependent proliferation of HTLV-l-positive thymocytes, most of them displaying a CD2+CD3-CD4+ phenotype and expressing the CD25 molecule, the a chain of the
منابع مشابه
Human immature thymocytes as target cells of the leukemogenic activity of human T-cell leukemia virus type I.
The risk of developing adult T-cell leukemia (ATL) associated with neonatal infection by human T-cell leukemia virus type I (HTLV-I) suggests that early events triggered by HTLV-I might be of crucial importance in initiating the multistep lymphoproliferative process leading several decades later to the development of leukemic disease. Thus, infection of thymocytes early in life might be directl...
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